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Semin Med Pract 
2004 ;7:12-23
Applying evidence to the care of a patient with bacterial meningitis: how to evaluate a therapeutic option
Nicholson LJ

Therapeutic decisions can be particularly challenging when they must be made urgently due to the high morbidity or mortality associated with a suspected diagnosis. This article uses the scenario of a patient with acute bacterial meningitis to demonstrate how filtered evidence resources can allow rapid access and review of high-quality evidence when faced with an urgent therapy decision. Also examined are the skills needed to appraise a therapy study and to apply its results to the patient at hand or to future patients. In the setting of an illness with high morbidity and mortality, these skills allow the physician to apply important new scientific data that may save lives.

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