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Answer 6
- There is no interaction between valproate sodium and oral contraceptive pills.
Some antiepileptic drugs, such as phenobarbital, primidone, phenytoin, carbamazepine, oxcarbazepine, and topiramate, are enzyme inducers and have been shown to increase the metabolism of ethinyl estradiol and progestogens.5 However, valproate sodium does not have this interaction and contraceptive preparations in normal doses can be used in patients taking valproate sodium.
REFERENCES
5. Crawford P. Interactions between antiepileptic drugs and hormonal contraception. CNS Drugs 2002;16:263–72.
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