Gastroesophageal reflux causing heartburn is a common symptom in pregnancy and is seen in 60% to 70% of pregnant patients. Antacids are considered safe, especially in the second and third trimesters. H2RAs and PPIs are designated by the US Food and Drug Administration as pregnancy category B or C drugs and are to be avoided if possible. Promotility agents are likewise category B or C drugs. An antispasmodic would be of little help in this situation.
